Analgesic Anti-inflammatory Patches
For ACUTE inflammatory conditions.
Tei-Kok Inc., Japan.
NITOFEN- Pharmacological details
1.
Contents:
A patch contains 20mg Ketoprufen (active compound), Liquid paraffin,
l-Menthol, Crotamiton, Alicyclic saturated hydrocarbon resin,
Styrene-isoprene-styrene block Co-polymer, Butylated hydroxyl toluene
& Polybutene.
2.
Physical
Characters:
Plasters impregnated with translucent colorless adhesive glue extended on
the backing material with a mild odour. Size 7CM X 14 CM Reorder Code
KP-07.
3.
Pharmacological
characters:
Ketoprufen (Generic name)
(RS)-2-(3-Benzoylphenyl)
Propanic acid, C16H14O3; Mol Weight: 254.28; Melting Point: 94-97 C.
White
crystalline Powder, soluble in Methanol, Freely soluble in Ethanol (95) or
Diethyl Ether; insoluble in H2O.
4.
Indications:
Analgesia- anti inflammation in the following conditions when accompanied
by chronic symptoms: Lumbago, Muscular facial lumbago, Spondylisis
deformans, lumbar sprain, Osteoarthritis, Periarthritis, Tendinitis,
Peritendinitis, Tennis elbow etc.,
Dosage: once every day on the affected area
5-1:
General Warning: A. This drug gives symptomatic relief from inflammation and pain due to
causes like injury etc but it doesn’t treat the underlying cause of such
symptoms. B. On areas with infection, this has to be used in addition to
treating the infection. C. Chronic disorders may warrant additional
treatment apart from this. D. When using for long periods, beware of
direct and indirect adverse reactions.
5-2:
Contra indications: A. Don’t use
in patients who have past history of topical allergy (erythema, rash etc)
or systemic allergy to similar drug previously. B.Don’t use in patients
who have allergy or symptoms of Asthma followed by usage of Aspirin or
anti-histamines. Extra care to be applied while using in patients with
Bronchial asthma as this may provoke the existing Asthmatic problem.
5-3:
Ketoprufen enhances the effect of Methotrexate and inhibits its renal
clearance
5-4:
Adverse reactions: Look for symptoms of contact dermatitis, photosensitivity,
anaphylaxis, asthmatic attack (especially in patients sensitive to
aspirin) and local adverse reactions like rashes, swelling, irritation and
if they develop, stop using and consult the physician to take remedial
measures
5-5:
Warning to pregnant women: Please inform your physician about pregnancy as the safety
of this medication during pregnancy, lactation as well as usage in
children, infants and elderly has not been established.
5-6:
Photosensitivity: Contact dermatitis and photosensitivity are likely and so the area of
application should be protected from exposure to sunlight especially UV
light during as well as a few weeks after application with proper measures
6.
Don’t use this product on mucous membrane, ulcer or open wounds and
Eczema. When necessary fix the patch with surgical adhesive tape.
7.
The Pharmaco kinetics: Plasma Ketoprufen concentrations following a single dosage
of 20mg plaster when applied on the back skin of 20 healthy male
volunteers reached a peak level app. 9.1 Hrs after application.
Cmax (ng/mL) 184.36+58.6; Tmax (hr): 9.1+2.2; AUC0 > 48 (ng.hr/mL): 3385.86+1275.84
Pharmacology: Inhibitory activities on Carragenin induced hind paw edema and adjuvant arthritis models of rats when studied has proven the efficacy of this patch and also the analgesic effect were also more potent with this than non-treated controls of rats when quantified by the Randall-Selitto techniques.For enquiries contact us at +91-44-23720805 or by email: info@nichiin.com